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CDCA2 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1645.54 SEK - 4652.90 SEK
Specifications
Antigen | CDCA2 |
---|---|
Concentration | 0.31 mg/mL |
Applications | Immunocytochemistry, Immunoprecipitation, Immunofluorescence, Western Blot |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Prezzo | QuantitĂ e disponibilitĂ | |||||
---|---|---|---|---|---|---|---|---|---|
Codice del prodotto | Marca | Quantity | Prezzo | QuantitĂ e disponibilitĂ | |||||
16897634
|
Proteintech
17701-1-AP-20UL |
20 ÎĽL |
1645.54 SEK
20µL |
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16887634
|
Proteintech
17701-1-AP-150UL |
150 ÎĽL |
4652.90 SEK
150µL |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Descrizione
Cell division cycle associated 2 (CDCA2, Repo-Man) is a cell-cycle protein that recruits protein phosphatase 1 (PP1) to mitotic chromatin at anaphase onset, which is essential for cell proliferation. Carboxy-terminal phosphorylation of CDCA2 at Ser893 by Aurora B inhibits the protein and leads to diffuse localization during prometaphase and metaphase. Dephosphorylation of CDCA2 by PP2A is necessary for CDCA2/PP1 complex reformation. The CDCA2/PP1 complex is required for chromatin binding and dephosphorylation of histone H3 at Thr3, Ser10, and Ser28. The CDCA2/PP1 complex is also involved in nuclear envelope reformation during mitotic exit for proper progression through the M/G1 transition. The interaction of CDCA2 with importin beta and Nup153, which is required for nuclear envelope formation, is negatively regulated by CDK phosphorylation of the amino-terminal domain of CDCA2. CDCA2 may play a role in DNA repair as the release of CDCA2 from chromatin at sites of DNA damage promotes the activation of DNA damage response. These results imply that the CDCA2/PP1 complex may play a part in cancer progression. Research studies indicate that CDCA2 may serve as a prognostic marker, as increased CDCA2 expression is seen in a number of cancers, including melanoma, neuroblastoma tumors, squamous cell carcinoma, and synovial sarcomas.Specifica
CDCA2 | |
Immunocytochemistry, Immunoprecipitation, Immunofluorescence, Western Blot | |
Unconjugated | |
Rabbit | |
Human | |
Q69YH5 | |
157313 | |
CDCA2 Fusion Protein Ag11967 | |
Primary | |
-20°C | |
CDCA2 |
0.31 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
CDCA2, Repo Man | |
CDCA2 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |
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Titolo del prodotto
CDCA2 Rabbit anti-Human, Polyclonal, Proteintech