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CLDN16 Rabbit anti-Canine, Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen CLDN16
Concentration 0.2 mg/mL
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16825755
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Proteintech
27638-1-AP-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 03-04-2024
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16815755
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Proteintech
27638-1-AP-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 03-04-2024
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Description

Description

Tight junction group of proteins are a cell-to-cell adhesion structure in epithelial cells that constitute the epithelial junctional complex with adherens junctions and desmosomes. Tight junction strands are mainly composed of claudins, occludin, and JAM. Claudin-16 belongs to the Claudin family of protein which is composed of 23 integral membrane proteins. Claudins are responsible for the formation of tight junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle′s loop (a TAL marker) are used to localize this specific structure of nephrons in kidney sections. Mg2+ resorption occurs in TAL, and Claudin-16 is required for this paracellular function. Failure in renal ′handling′ of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems.
Specifications

Specifications

CLDN16
Western Blot
Unconjugated
Rabbit
Human, Canine
Q9Y5I7
10686, 608218
CLDN16 Fusion Protein Ag26531
Primary
-20°C
CLDN16
0.2 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
claudin 16, CLDN16, HOMG3, Paracellin 1, PCLN 1, PCLN1
CLDN16
IgG
Antigen Affinity Chromatography
Antibody
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Documents

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