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CLDN16 Rabbit anti-Canine, Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1656.73 SEK - 4721.67 SEK
Specifications
Antigen | CLDN16 |
---|---|
Concentration | 0.2 mg/mL |
Applications | Western Blot |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16825755
|
Proteintech
27638-1-AP-20UL |
20 μL |
1656.73 SEK
20µL |
Estimated Shipment: 03-04-2024 Log in to see stock. |
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16815755
|
Proteintech
27638-1-AP-150UL |
150 μL |
4721.67 SEK
150µL |
Estimated Shipment: 03-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Tight junction group of proteins are a cell-to-cell adhesion structure in epithelial cells that constitute the epithelial junctional complex with adherens junctions and desmosomes. Tight junction strands are mainly composed of claudins, occludin, and JAM. Claudin-16 belongs to the Claudin family of protein which is composed of 23 integral membrane proteins. Claudins are responsible for the formation of tight junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle′s loop (a TAL marker) are used to localize this specific structure of nephrons in kidney sections. Mg2+ resorption occurs in TAL, and Claudin-16 is required for this paracellular function. Failure in renal ′handling′ of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems.Specifications
CLDN16 | |
Western Blot | |
Unconjugated | |
Rabbit | |
Human, Canine | |
Q9Y5I7 | |
10686, 608218 | |
CLDN16 Fusion Protein Ag26531 | |
Primary | |
-20°C | |
CLDN16 |
0.2 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
claudin 16, CLDN16, HOMG3, Paracellin 1, PCLN 1, PCLN1 | |
CLDN16 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |