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CLSTN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12788-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16880684

  • 3313.85 SEK / 150µL
Estimated Shipment: 02-12-2021

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Description

Description

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
Specifications

Specifications

CLSTN1
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O94985, Q6Q0N0, Q9EPL2
ALC ALPHA, Alcadein alpha, alcalpha1, alcalpha2, C terminal fragment 1 alpha, calsyntenin 1, CLSTN1, CS1, CSTN1, KIAA0911, PIK3CD, SAlc alpha CTF1 alpha, XB31alpha
Rabbit
IgG
150 μL
-20°C
Primary
22883, 313717, 65945
Western Blot
Unconjugated
CLSTN1
Liquid
Clstn1
CLSTN1 Fusion Protein Ag3504
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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