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CLSTN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12788-1-AP-150UL
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Description
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.Specifications
| CLSTN1 | |
| Polyclonal | |
| Unconjugated | |
| CLSTN1 | |
| ALC ALPHA, Alcadein alpha, alcalpha1, alcalpha2, C terminal fragment 1 alpha, calsyntenin 1, CLSTN1, CS1, CSTN1, KIAA0911, PIK3CD, SAlc alpha CTF1 alpha, XB31alpha | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 22883, 313717, 65945 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 0.27 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| O94985, Q6Q0N0, Q9EPL2 | |
| Clstn1 | |
| CLSTN1 Fusion Protein Ag3504 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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Product Title
CLSTN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 150 μL; Unconjugated
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