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DLAT Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 13426-1-AP-20UL
Additional Details : Weight : 0.00010kg
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DescriptionDLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure.
|DLAT, DLTA, PBC, PDC E2, PDCE2|
|Antigen Affinity Chromatography|
|1737, 235339, 81654|
|Immunocytochemistry, Immunoprecipitation, Immunofluorescence, Western Blot|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P08461, P10515, Q8BMF4|
|DLAT Fusion Protein Ag4226|
|Rat, Human, Mouse|