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DLAT Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 13426-1-AP-20UL

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Product Code. 16881634

  • 1645.54 SEK / 20µL

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Description

Description

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure.
Specifications

Specifications

DLAT
Polyclonal
Unconjugated
DLAT
DLAT, DLTA, PBC, PDC E2, PDCE2
Rabbit
Antigen Affinity Chromatography
RUO
1737, 235339, 81654
-20°C
Liquid
Western Blot, Immunofluorescence, Immunoprecipitation, Immunocytochemistry
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P08461, P10515, Q8BMF4
DLAT
DLAT Fusion Protein Ag4226
20 μL
Primary
Mouse, Human, Rat
Antibody
IgG
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