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DLL4 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 21584-1-AP-150UL
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Description
DLL4 (Delta-like ligand 4, Delta-4) is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.Specifications
| DLL4 | |
| Polyclonal | |
| Unconjugated | |
| DLL4 | |
| delta like 4 (Drosophila), Delta like protein 4, Delta4, DLL4, Drosophila Delta homolog 4, hdelta2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 54485, 54567 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot | |
| 0.22 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| Q9JI71, Q9NR61 | |
| Dll4 | |
| DLL4 Fusion Protein Ag16140 | |
| 150 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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Product Title
DLL4 Rabbit anti-Human, Mouse, Polyclonal, Proteintech > 150 μL; Unconjugated
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