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DLL4 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 21584-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
DLL4 (Delta-like ligand 4, Delta-4) is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.Specifications
DLL4 | |
Polyclonal | |
Unconjugated | |
DLL4 | |
delta like 4 (Drosophila), Delta like protein 4, Delta4, DLL4, Drosophila Delta homolog 4, hdelta2 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
54485, 54567 | |
-20°C | |
Liquid |
Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry | |
0.22 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q9JI71, Q9NR61 | |
Dll4 | |
DLL4 Fusion Protein Ag16140 | |
150 μL | |
Primary | |
Mouse, Human | |
Antibody | |
IgG |