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Docetaxel, 99%, Thermo Scientific™
Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities.
1638.65 SEK - 8581.65 SEK
Kemiska identifierare
| CAS | 114977-28-5 |
|---|---|
| Molekylformel | C43H53NO14 |
| Molekylvikt (g/mol) | 807.89 |
| MDL-nummer | MFCD00800737 |
| InChI-nyckel | ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
| Synonym | docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl |
| PubChem CID | 148124 |
| ChEBI | CHEBI:4672 |
| LEDER | CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
| Produktkod | Brand | Kvantitet | Pris | Kvantitet och tillgänglighet | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktkod | Brand | Kvantitet | Pris | Kvantitet och tillgänglighet | |||||
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15462989
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Thermo Scientific Alfa Aesar
J60174.MC |
100mg |
 1824.98 SEK 1638.65 SEK / 100mg Save 186.33 SEK 10% Av |
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15472989
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Thermo Scientific Alfa Aesar
J60174.ME |
500mg |
5775.39 SEK 5184.65 SEK / 500mg Save 590.74 SEK 10% Av |
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15452989
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Thermo Scientific Alfa Aesar
J60174.03 |
1g |
9558.89 SEK 8581.65 SEK / 1g Save 977.24 SEK 10% Av |
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death
Application
• Docetaxel can inhibit angiogenesis both in vitro and in vivo by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells
• Some in vitro and in vivo studies have been performed in order to understand if the combination of docetaxel with stearidonic acid enhances cell death in human prostate cancer cells
• It has been used in vitro in prostate cancer stem-like cells (PCSCs) to test its effect on the notch signaling pathway
Chemical Identifiers
| 114977-28-5 | |
| 807.89 | |
| ZDZOTLJHXYCWBA-VCVYQWHSSA-N | |
| 148124 | |
| CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
| C43H53NO14 | |
| MFCD00800737 | |
| docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl | |
| CHEBI:4672 |
Spécification
| Docetaxel | |
| C43H53NO14 | |
| 14,3397 | |
| Soluble in dimethyl sulfoxide and ethanol; Insoluble in water. | |
| CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O | |
| 148124 | |
| 807.88 |
| 114977-28-5 | |
| MFCD00800737 | |
| docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl | |
| ZDZOTLJHXYCWBA-VCVYQWHSSA-N | |
| 807.89 | |
| CHEBI:4672 | |
| 99% |
Sécurité et traitement
P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
H315-H319-H335-H361fd
missing translation for 'rtecsNumber' : DA4172750
missing translation for 'tsca' : No
Recommended Storage : Store at -20°C
RUO – Research Use Only
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