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E2F1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12171-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of E2F1 protein, specifically recognizes the 47 kDa human E2F1 protein. The sumoylated E2F1 is bout 55 kDa.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.Specifications
E2F1 | |
Polyclonal | |
Unconjugated | |
E2F1 | |
E2F 1, E2F transcription factor 1, E2F1, PBR3, PRB binding protein E2F 1, RBAP 1, RBAP1, RBBP 3, RBBP3, Transcription factor E2F1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
13555, 1869, 399489 | |
-20°C | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin) | |
0.31 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
O09139, Q01094, Q61501 | |
E2F1 | |
E2F1 Fusion Protein Ag2813 | |
20 μL | |
Primary | |
Rat, Human, Mouse | |
Antibody | |
IgG |