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E2F1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12171-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16839723

  • 1236.20 SEK / 20µL
Estimated Shipment: 05-10-2022
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Description

Description

This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of E2F1 protein, specifically recognizes the 47 kDa human E2F1 protein. The sumoylated E2F1 is bout 55 kDa.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Specifications

Specifications

E2F1
Polyclonal
Unconjugated
E2F1
E2F 1, E2F transcription factor 1, E2F1, PBR3, PRB binding protein E2F 1, RBAP 1, RBAP1, RBBP 3, RBBP3, Transcription factor E2F1
Rabbit
Antigen Affinity Chromatography
RUO
13555, 1869, 399489
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.31 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O09139, Q01094, Q61501
E2F1
E2F1 Fusion Protein Ag2813
20 μL
Primary
Mouse, Human, Rat
Antibody
IgG
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