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EIF2AK2 Mouse anti-Human, Clone: 2A8A4, Proteintech

Mouse Monoclonal Antibody

1236.20 SEK - 3313.85 SEK

Specifications

Antigen EIF2AK2
Concentration 1 mg/mL
Applications Western Blot, Immunohistochemistry (Paraffin)
Conjugate Unconjugated
Format Liquid
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16878715
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Proteintech
66646-1-IG-150UL
150 μL
3313.85 SEK
150µL
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Estimated Shipment: 31-01-2022
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16888715
View Documents Promotion Details
Proteintech
66646-1-IG-20UL
20 μL
1236.20 SEK
20µL
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Estimated Shipment: 31-01-2022
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Description

Description

This antibody is specific to EIF2AK2.

PKR is a 68 kDa protein and an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & maligcy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Specifications

Specifications

EIF2AK2
Western Blot, Immunohistochemistry (Paraffin)
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Monoclonal
-20°C
1 mg/mL
Unconjugated
Mouse
Human
IgG1
Protein G
Antibody
SDS
Product Certifications