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EYA2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11314-1-AP-20UL
Additional Details : Weight : 0.00010kg
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DescriptionFunctions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates ′Tyr- 142′ of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ′Tyr-142′ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
|EAB1, EYA2, Eyes absent homolog 2|
|Antigen Affinity Chromatography|
|14049, 156826, 2139|
|Western Blot, Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin)|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|EYA2 Fusion Protein Ag1860|
|Rat, Human, Mouse|