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Factor XII Mouse anti-Human, Clone: 2E2F11, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66089-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16887645

  • 3313.85 SEK / 150µL
Estimated Shipment: 02-12-2021

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Description

Description

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Specifications

Specifications

Factor XII
2E2F11
Unconjugated
F12
Liquid
F12
Factor XII Fusion Protein Ag3401
Protein A
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1.28 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P00748
Factor XII, Coagulation factor XII, F12, HAE3, HAEX, HAF, Hageman factor
Mouse
IgG2b
150 μL
-20°C
Primary
2161
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