missing translation for 'onlineSavingsMsg'
Learn More

Factor XIIIa Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Specifications

Antigen Factor XIIIa
Concentration 0.13 mg/mL
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16887074
View Documents Promotion Details
Proteintech
17223-1-AP-20UL
20 μL N/A
View alternative products
Save Up to 
»
N/A
16877074
View Documents Promotion Details
Proteintech
17223-1-AP-150UL
150 μL N/A
View alternative products
Save Up to 
»
N/A
Description

Description

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Specifications

Specifications

Factor XIIIa
Western Blot
Unconjugated
Rabbit
Human, Rat, Mouse
O08619, P00488, Q8BH61
2162, 60327, 74145
Factor XIIIa Fusion Protein Ag11059
Primary
-20°C
F13A1
0.13 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Coagulation factor XIIIa, F13A, F13A1, Transglutaminase A chain
F13a1
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications