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FAK Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1645.54 SEK - 4652.90 SEK

Specifica

Antigen FAK
Concentration 0.53 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
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Prodotti 2
Codice del prodotto Marca Quantity Prezzo QuantitĂ  e disponibilitĂ   
Codice del prodotto Marca Quantity Prezzo QuantitĂ  e disponibilitĂ   
16890454
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Proteintech
12636-1-AP-20UL
20 ÎĽL
1645.54 SEK
20µL
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16880454
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Proteintech
12636-1-AP-150UL
150 ÎĽL
4652.90 SEK
150µL
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Descrizione

Descrizione

Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and involved in its initial activation. This phosphorylated site binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis. Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.
Specifica

Specifica

FAK
Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
Unconjugated
Rabbit
Human, Rat, Mouse
O35346, P34152, Q05397
14083, 25614, 5747
FAK Fusion Protein Ag3331
Primary
-20°C
PTK2
0.53 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
FADK, FADK 1, FAK, FAK1, Focal adhesion kinase 1, pp125FAK, Protein tyrosine kinase 2, PTK2, PTK2 protein tyrosine kinase 2
PTK2
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documenti

Documenti

Certificati
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Titolo del prodotto
FAK Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

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