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FGFR2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 13042-1-AP-20UL
Additional Details : Weight : 0.00010kg
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This polyclonal antibody raised against 358-704 aa of human FGFR2 can cross react with other members of the FGFR family.The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
|BEK, BFR 1, CD332, CEK3, CFD1, ECT1, FGFR 2, FGFR2, JWS, K SAM, KGFR, KSAM, TK14, TK25|
|Antigen Affinity Chromatography|
|14183, 2263, 25022|
|Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|FGFR2 Fusion Protein Ag3701|
|Rat, Mouse, Human|