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Gibco™ Mouse IL-1 beta Recombinant Protein Product Code.: 10324543
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Gibco™ Mouse IL-1 beta Recombinant Protein

Product Code. 10324543
100 μg, Each
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For Research Use Only. All usage must comply with product instructions.

Product Code. 10324543

Brand: Gibco™ PMC0811

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This item is not returnable. View return policy

For Research Use Only. All usage must comply with product instructions.

Description

Recombinant Protein

Mouse IL-1 beta Recombinant Protein for Western Blot, IHC, ELISA, Ctrl, FN

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P10749
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 16176
Molecular Weight (g/mol) 17 kDa
Name Mouse IL-1 beta
Purification Method Sequential Chromatography
Quantity 100 μg
Endotoxin Concentration <0.1 ng/ μg
Gene Alias catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1 b; IL 1β; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1 B; IL1B1; IL1beta; IL-1 beta; IL1-BETA; IL1F2; IL1β; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 b; interleukin-1 beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
Common Name IL-1 beta
Biological Activity ED50 < 10 pg/mL; determined by the dose-dependent proliferation of murine D10S cells.
Conjugate Unconjugated
Species Mouse
Recombinant Recombinant
Sequence VPIRQLHYRL RDEQQKSLVL SDPYELKALH LNGQNINQQV IFSMSFVQGE PSNDKIPVAL GLKGKNLYLS CVMKDGTPTL QLESVDPKQY PKKKMEKRFV FNKIEVKSKV EFESAEFPNW YISTSQAEHK PVFLGNNSGQ DIIDFTMESV SS
Content And Storage 4°C
Classification Carrier-Free
Endotoxin Level <0.1 ng/μg
Shipping Condition Wet Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype Interleukins
Research Category Stem Cell Research, Immunology
Purity or Quality Grade >95% by SDS-PAGE
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Lot Number2642953 Certificate TypeCertificate of Analysis Date25/02/2023 Product CodePMC0811
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