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Gibco™ Mouse IL-1 beta Recombinant Protein
Recombinant Protein
1762.00 SEK - 20600.00 SEK
Specifications
Accession Number | P10749 |
---|---|
For Use With (Application) | Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot |
Formulation | protein with no preservative |
Gene ID (Entrez) | 16176 |
Molecular Weight (g/mol) | 17 kDa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
10324543
|
Gibco™
PMC0811 |
100 ÎĽg |
20600.00 SEK
Each |
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10444943
|
Gibco™
PMC0814 |
5 ÎĽg |
1762.00 SEK
Each |
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10191193
|
Gibco™
PMC0815 |
10 ÎĽg |
2920.00 SEK
Each |
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10354303
|
Gibco™
PMC0816 |
25 ÎĽg |
5770.00 SEK
Each |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Mouse IL-1 beta Recombinant Protein for Western Blot, IHC, ELISA, Ctrl, FN
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.Specifications
P10749 | |
protein with no preservative | |
17 kDa | |
Sequential Chromatography | |
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1 b; IL 1β; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1 B; IL1B1; IL1beta; IL-1 beta; IL1-BETA; IL1F2; IL1β; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 b; interleukin-1 beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta | |
ED50 < 10 pg/mL; determined by the dose-dependent proliferation of murine D10S cells. | |
Mouse | |
VPIRQLHYRL RDEQQKSLVL SDPYELKALH LNGQNINQQV IFSMSFVQGE PSNDKIPVAL GLKGKNLYLS CVMKDGTPTL QLESVDPKQY PKKKMEKRFV FNKIEVKSKV EFESAEFPNW YISTSQAEHK PVFLGNNSGQ DIIDFTMESV SS | |
Carrier-Free | |
E. coli | |
Recombinant, Ligand | |
Interleukins |
Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot | |
16176 | |
Mouse IL-1 beta | |
<0.1 ng/ ÎĽg | |
IL-1 beta | |
Unconjugated | |
Recombinant | |
4°C | |
<0.1 ng/ÎĽg | |
Cytokines & Receptors | |
Lyophilized | |
>95% by SDS-PAGE |
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Product Title
Gibco™ Mouse IL-1 beta Recombinant Protein