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Gibco™ Mouse IL-1 beta Recombinant Protein

Recombinant Protein

1762.00 SEK - 20600.00 SEK

Specifications

Accession Number P10749
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 16176
Molecular Weight (g/mol) 17 kDa
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
10324543
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Gibco™
PMC0811
100 ÎĽg
20600.00 SEK
Each
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10444943
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Gibco™
PMC0814
5 ÎĽg
1762.00 SEK
Each
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10191193
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Gibco™
PMC0815
10 ÎĽg
2920.00 SEK
Each
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10354303
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Gibco™
PMC0816
25 ÎĽg
5770.00 SEK
Each
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Description

Description

Mouse IL-1 beta Recombinant Protein for Western Blot, IHC, ELISA, Ctrl, FN

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
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