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GNAS Mouse anti-Human, Porcine, Clone: 1A9C10, Proteintech

Mouse Monoclonal Antibody

1645.54 SEK - 4652.90 SEK

Specifications

Antigen GNAS
Clone 1A9C10
Concentration 1 mg/mL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16887955
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Proteintech
66253-1-IG-20UL
20 μL
1645.54 SEK
20µL
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16877955
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Proteintech
66253-1-IG-150UL
150 μL
4652.90 SEK
150µL
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Description

Description

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5′ exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5′ exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal domit inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described; however, their full length sequences have not been determined.
Specifications

Specifications

GNAS
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
AHO, C20orf45, GNAS, GNAS complex locus, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, POH, Protein ALEX
GNAS
IgG2b
Protein A
Antibody
1A9C10
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Mouse
Human, Pig
P29797, P84996
100049657, 2778
GNAS Fusion Protein Ag20530
Primary
-20°C
GNAS
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SDS
Documents

Documents

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GNAS Mouse anti-Human, Porcine, Clone: 1A9C10, Proteintech

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