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GSK2578215A
Potent, selective LRRK2 inhibitor; brain penetrant
Marca: Tocris Bioscience 4629/5
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Descripción
GSK2578215A is a potent LRRK2 inhibitor (IC50 values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 over a panel of 460 other kinases. Blocks Ser910 and Ser935 phosphorylation in vitro and in peripheral tissues in vivo. Brain penetrant.Especificaciones
| 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide | |
| >99% | |
| C24H18FN3O2 |
| 1285515-21-0 | |
| 5 mg | |
| Observed MW: 399.42 |