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GUCY1A3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12605-1-AP-20UL

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Product Code. 16890404

  • 1645.54 SEK / 20µL

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Description

Description

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
Specifications

Specifications

GUCY1A3
Polyclonal
Unconjugated
GUCY1A3
GC SA3, GCS alpha 1, GCS alpha 3, GUC1A3, GUCA3, GUCSA3, GUCY1A1, GUCY1A3
Rabbit
Antigen Affinity Chromatography
RUO
2982, 497757, 60596
-20°C
Liquid
Immunoprecipitation, Immunohistochemistry (Paraffin), Western Blot
0.26 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P19686, Q02108, Q9ERL9
Gucy1a3
GUCY1A3 Fusion Protein Ag3293
20 μL
Primary
Human, Rat, Mouse
Antibody
IgG
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Product Title
GUCY1A3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated

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