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Gibco™ Human IL-23 Recombinant Protein, PeproTech® Product Code.: 17890433

Gibco™ Human IL-23 Recombinant Protein, PeproTech®

Product Code. p-7246355
100 μg, 100µg
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Quantity:
10 μg
100 μg
2 μg
2 x 500 μg
250 μg
50 μg
500 μg
Unit Size:
100µg
10µg
1mg
250µg
2µg
500µg
50µg
Pack of 2
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Product Code. 17890433

Brand: Gibco™ 20023100UG

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This item is not returnable. View return policy

Recombinant Protein

200-23-1MG will be provided as 2 x 500 μg (200-23-500UG). Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids). This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 that is disulfide-linked with to two subunits, a p19 subunit unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 interacts with IL-12Rbeta1 and a beta2-like receptor subunit with STAT4 binding domain, IL-23R. IL-23 is secreted by activated mouse and human dendritic cells and is involved in the inflammation process and associated with autoimmune diseases. Mouse IL-23 was found not to induce significant amounts of IFN-gamma, induces strong proliferation of memory T cells (but not naive T cells), and activate mouse memory T cells to produce the proinflammatory cytokine IL-17. On the other hand, human IL-23 induces proliferation of memory T cells, induces moderate levels of IFN-gamma, and is produced by naive and memory T cells. IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance, and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines. IL-23 interacts with the receptors IL-12R beta1 and IL-23R to activate the Jak-Stat signaling cascade. IL-23 has been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NPF7
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 51561
Molecular Weight (g/mol) 53.5 kDa
Name Human IL-23
Quantity 100 μg
Source Insect cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias IL23; IL-23; IL-23 subunit alpha; IL23A; IL-23 A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; P19; SGRF; UNQ2498/PRO5798
Common Name IL-23
Gene Symbol IL23A
Biological Activity Measured by its ability to induce IL-17 secretion by mouse splenocytes.
Conjugate Unconjugated
Recombinant Recombinant
Sequence p19 subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
Content And Storage -20°C
Expression System Insect cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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