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STEMCELL Technologies Human Recombinant IL-15
Interleukin 15
Brand: STEMCELL Technologies 78031.1
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Description
- Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor
- The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra, the high-affinity receptor for IL-15, as well as IL-2/15Rb (CD122) and common gamma chain (CD132)
- IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells
- Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.) The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways
- IL-15 supports the survival and proliferation of naive CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells
- IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.)
Specifications
| IL-T, Interleukin-15 | |
| 10 μg | |
| Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells | |
| ≥95% |
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STEMCELL Technologies Human Recombinant IL-15
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