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STEMCELL Technologies Human Recombinant IL-5, ACF

Interleukin 5, animal component-free

Specifications

Name B-cell differentiation factor I, EDF, Eosinophil colony-stimulating factor, Eosinophil differentiation factor, Interleukin-5, T-cell replacing factor, TRF
Cell Type B Cells; Granulocytes and Subsets; Hematopoietic Stem and Progenitor Cells
Purity or Quality Grade ≥95%
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Description

Description

  • Interleukin 5 (IL-5) is a member of the short-chain 4-α-helical bundle subset of hematopoietic cytokines
  • It binds to a receptor consisting of IL-5Ra, which is specific for IL-5R and common beta chain, which is shared with the receptor for IL-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF; Martinez-Moczygemba & Huston)
  • Upon binding to its receptor, IL-5 activates the JAK/STAT and MAPK pathways
  • IL-5 is produced by Th2 cells, eosinophils, and activated mast cells
  • It functions in the recruitment, activation, proliferation, and survival of eosinophils, thus playing an important role in allergic inflammation, asthma, and parasite immunity
  • Stimulation of eosinophils with IL-5 leads to their activation, upregulation of CD11b expression, and inhibition of apoptosis (Martinez-Moczygemba & Huston)
  • This product is animal component-free
Specifications

Specifications

B-cell differentiation factor I, EDF, Eosinophil colony-stimulating factor, Eosinophil differentiation factor, Interleukin-5, T-cell replacing factor, TRF
B Cells; Granulocytes and Subsets; Hematopoietic Stem and Progenitor Cells
≥95%
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