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IFN gamma Rat anti-Mouse, Functional Grade, Clone: R4-6A2, eBioscience™

Rat Monoclonal Antibody

872.00 SEK - 15890.00 SEK

Specifications

Antigen IFN gamma
Clone R4-6A2
Target Species Mouse
Conjugate Functional Grade
Isotype IgG1, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15557816 View Documents Affymetrix eBioscience
16-7312-38
5 mg 15890.00 SEK
5mg View alternative products
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Estimated Shipment date
from Supplier 20-05-2020
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15298787 View Documents Affymetrix eBioscience
16-7312-81
50 μg 872.00 SEK
50µg View alternative products
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Estimated Shipment date
from Supplier 20-05-2020
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15208797 View Documents Affymetrix eBioscience
16-7312-85
500 μg 2555.00 SEK
500µg View alternative products
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EU Stock 3
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Description

Description

Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
Specifications

Specifications

IFN gamma
Mouse
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
R4-6A2
Functional Grade
Functional Assay, Neutralization
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO

For Research Use Only.