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IGF2R Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20253-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16879774

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

The antibody is specific to IGF2R.

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR′s is predomitly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An approximately 240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.
Specifications

Specifications

IGF2R
0.42 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P11717
CD222, CI Man 6 P receptor, CI MPR, CIMPR, IGF II receptor, IGF2R, M6P R, M6P/IGF2 receptor, M6P/IGF2R, M6PR, MPR 300, MPR1, MPRI
Rabbit
IgG
20 μL
-20°C
Primary
3482
Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Unconjugated
IGF2R
Liquid
IGF2R
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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