ITGA6X1A Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20231-1-AP-20UL
Additional Details : Weight : 0.00010kg
DescriptionE3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
|CD49f, Integrin alpha 6, integrin, alpha 6, ITGA6, ITGA6B, VLA 6|
|Antigen Affinity Chromatography|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|