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Invitrogen™ Ly-6G Monoclonal Antibody (1A8-Ly6g), PE-eFluor™ 610, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen™ 61-9668-80

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CĂłdigo de producto. 15560577

  • 1576.00 SEK / 25µg

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DescripciĂłn

DescripciĂłn

Description: The monoclonal antibody 1A8-Ly6g reacts with mouse Ly-6G, which is also known as Gr-1. Ly-6G is a 25-kDa GPI protein expressed exclusively by neutrophils. Studies suggest an important role in neutrophil infiltration, recruitment and migration. Ly-6G associates with B2 integrins CD11a and CD11b and can attenuate B2 integrin expression and function. The ligand for Ly-6G is currently unknown. Unlike the RB6-8C5 antibody, 1A8-Ly6g is reported to only bind to Ly-6G found on neutrophils. Moreover, 1A8-Ly6g has been used to deplete neutrophils and reported to have antagonist activity. Applications Reported: This 1A8-Ly6g antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1A8-Ly6g antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. PE-eFluor™ 610 can be excited with laser lines from 488-561 nm and emits at 607 nm. We recommend using a 610/20 band pass filter (equivalent to PE-Texas Red™). Please make sure that your instrument is capable of detecting this fluorochome.

Ly6G (Lymphocyte antigen 6 complex locus G6D) is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. The Ly6G protein has a molecular weight of approximately 21-25 kDa and is expressed by myeloid derived cells in the bone marrow. Ly6G is a good marker for detection of peripheral neutrophils, monocytes and granulocytes. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. The physiological role of Ly6G remains unclear but studies have shown its involvement in anti-tumor response, and studies with neutrophils suggest that Ly6G ligation may have an inhibitory effect on local immune responses.
TRUSTED_SUSTAINABILITY
Especificaciones

Especificaciones

Ly-6G
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P35461
Ly6g
Affinity chromatography
RUO
546644
4°C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
1A8-Ly6g
PE-eFluor 610
Ly6g
Gr1; Gr-1; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6G
Rat
25 ÎĽg
Primary
Mouse
Antibody
IgG2a Îş
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TĂ­tulo del producto
Invitrogen™ Ly-6G Monoclonal Antibody (1A8-Ly6g), PE-eFluor™ 610, eBioscience™, Invitrogen™ > 25 ÎĽg; PE-eFluor 610

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