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LYVE1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 51011-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16886265

  • 1211.96 SEK / 20µL
Estimated Shipment: 30-11-2021

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Description

Description

LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluro) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 is a type I integral membrane glycoprotein. LYVE-1 is expressed primarily on lymphatic vessel endothelium and is likely to be involved in regulating the traffic of leucocytes and tumor cells to lymph nodes. The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. A number of molecules have been identified as markers for lymphatic endothelium which include LYVE1, PALE, VEGFR3, and podoplanin. Diseases associated with LYVE1 dysfunction includes Complete Androgen Insensitivity Syndrome.
Specifications

Specifications

LYVE1
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9Y5Y7
CRSBP 1, CRSBP1, HAR, Hyaluronic acid receptor, LYVE 1, LYVE1, XLKD1
Rabbit
IgG
20 μL
-20°C
Primary
10894
Western Blot
Unconjugated
LYVE1
Liquid
LYVE1
LYVE1 Fusion Protein Ag0570
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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