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Invitrogen™ Human MAP3K8 (COT), GST Tag Recombinant Protein Product Code.: 15458633

Invitrogen™ Human MAP3K8 (COT), GST Tag Recombinant Protein

Product Code. p-7121801
100 μg, 100µg
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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Product Code. 15458633

Brand: Invitrogen™ PR7887A

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This item is not returnable. View return policy

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic

MAP3K8 (COT) is a serine/threonine kinase which can activate both the MAP and JNK kinase pathways and plays a role in the cell cycle. Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P41279
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50 mM tris HCl with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5
Gene ID (Entrez) 1326
Molecular Weight (g/mol) 69.9 kDa
Name Human MAP3K8 (COT), GST Tag
Quantity 100 μg
Regulatory Status RUO - research use only
Gene Alias augmented in rheumatoid arthritis 2; AURA2; Cancer Osaka thyroid oncogene; cancer Osaka thyroid, oncogene; CCOT; c-COT; COT; cot (cancer Osaka thyroid) oncogene; COT proto-oncogene serine/threonine-protein kinase; Cot/Tpl2; D17TPL2; EC 1.14.16.2; Est; Estf; Ewing sarcoma transformant; FLJ10486; M3K8; MAP3K 8; Map3k8; MEKK8; mitogen activated protein kinase kinase kinase 8; mitogen-activated protein kinase kinase kinase 8; Protein kinase cot; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; serine/threonine kinase (Tpl-2); serine/threonine-protein kinase cot; TH isoform 3; TH isoform a; TH-4; TPL 2; Tpl2; TPL-2; Tumor progression locus 2; TY3H; TYH
Common Name TPL2
KinaseFamily STE Unique Kinase Family
Protein Length 30-397
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Insect cells
Form Liquid
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Certificates

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2 results found
Lot Number Certificate Type Date Product Code
Lot Number2578622E Certificate TypeCertificate of Analysis Date21/02/2025 Product CodePR7887A
Lot Number2578622D Certificate TypeCertificate of Analysis Date23/02/2024 Product CodePR7887A
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