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MAP4K1 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1656.73 SEK - 4721.67 SEK
Specifications
Antigen | MAP4K1 |
---|---|
Concentration | 0.3 mg/mL |
Applications | Immunoprecipitation, Western Blot |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16882545
|
Proteintech
23950-1-AP-20UL |
20 μL |
1656.73 SEK
20µL |
Estimated Shipment: 22-04-2024 Log in to see stock. |
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16872545
|
Proteintech
23950-1-AP-150UL |
150 μL |
4721.67 SEK
150µL |
Estimated Shipment: 22-04-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predomitly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a domit-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.Specifications
MAP4K1 | |
Immunoprecipitation, Western Blot | |
Unconjugated | |
Rabbit | |
Human | |
Q92918 | |
11184 | |
MAP4K1 Fusion Protein Ag20221 | |
Primary | |
-20°C | |
MAP4K1 |
0.3 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
HPK1, MAP4K1, MEK kinase kinase 1, MEKKK 1 | |
MAP4K1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |