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MAP4K1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1645.54 SEK - 4652.90 SEK

Specifications

Antigen MAP4K1
Concentration 0.3 mg/mL
Applications Western Blot, Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16882545
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Proteintech
23950-1-AP-20UL
20 ÎĽL
1645.54 SEK
20µL
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16872545
View Documents
Proteintech
23950-1-AP-150UL
150 ÎĽL
4652.90 SEK
150µL
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Description

Description

The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predomitly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a domit-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.
Specifications

Specifications

MAP4K1
Western Blot, Immunoprecipitation
Unconjugated
Rabbit
Human
Q92918
11184
MAP4K1 Fusion Protein Ag20221
Primary
-20°C
MAP4K1
0.3 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
HPK1, MAP4K1, MEK kinase kinase 1, MEKKK 1
MAP4K1
IgG
Antigen Affinity Chromatography
Antibody
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SDS
Documents

Documents

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MAP4K1 Rabbit anti-Human, Polyclonal, Proteintech

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