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MBD2 Rabbit anti-Human, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 55200-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
This antibody is specific to MBD2. It recognize isoform1 and isoform2 of MBD2.
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.Specifications
MBD2 | |
Polyclonal | |
Unconjugated | |
MBD2 | |
Demethylase, DMTase, MBD2, NY CO 41 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
680172, 8932 | |
-20°C | |
Liquid |
Western Blot | |
0.28 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q9UBB5 | |
MBD2 | |
Peptide | |
20 μL | |
Primary | |
Rat, Human | |
Antibody | |
IgG |