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MHC Class II (I-A) Rat anti-Mouse, FITC, Clone: NIMR-4, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-5322-82

Additional Details : Weight : 0.25000kg

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Product Code. 15228239

  • 1452.00 SEK / 100µg


In stock, ready to ship: 3
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Description

Description

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
Specifications

Specifications

MHC Class II (I-A)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P06342
H2-Ab1
IgG2b
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
14961
Flow Cytometry
NIMR-4
FITC
H2-Ab1
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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