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NOVA2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 55002-1-AP-150UL
Additional Details : Weight : 0.00010kg
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The antibody is specific to NOVA2.Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against onconeural disease antigens that are expressed by gynecologic or lung tumors and by neurons. Nova-1 and -2 are both POMA disease antigens. The autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia. Nova-2 is closely related to Nova-1, and is expressed at high levels in neurons during development and at lower levels in the adult lung. In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus. Both Novas are RNA binding proteins, and Nova-2 binds RNA with high affinity and with sequence specificity that differs from Nova-1. They regulate neuronal pre-messenger RNA splicing by directly binding to RNA. Nova-2 target genes function either in the synapse or in axon guidance indicating that Nova-2 is a major regulator of synaptic function.
|ANOVA, NOVA2, NOVA3, RNA binding protein Nova 2|
|Antigen Affinity Chromatography|
|292681, 384569, 4858|
|Western Blot, Immunoprecipitation|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Rat, Mouse, Human|