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NPC1 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1656.73 SEK - 4721.67 SEK
Specifications
Antigen | NPC1 |
---|---|
Concentration | 0.32 mg/mL |
Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunofluorescence |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16892354
|
Proteintech
13926-1-AP-20UL |
20 μL |
1656.73 SEK
20µL |
Estimated Shipment: 14-05-2024 Log in to see stock. |
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16882354
|
Proteintech
13926-1-AP-150UL |
150 μL |
4721.67 SEK
150µL |
Estimated Shipment: 14-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.Specifications
NPC1 | |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunofluorescence | |
Unconjugated | |
Rabbit | |
Human | |
O15118 | |
4864 | |
NPC1 Fusion Protein Ag4946 | |
Primary | |
-20°C | |
NPC1 |
0.32 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Niemann Pick C1 protein, Niemann Pick disease, type C1, NPC1 | |
NPC1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |