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NUMB Mouse anti-Human, Mouse, Rat, Clone: 2G12B7, Proteintech

Mouse Monoclonal Antibody

1395.65 SEK - 3774.95 SEK

Specifications

Antigen	NUMB
Clone	2G12B7
Concentration	2 mg/mL
Applications	Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
Classification	Monoclonal

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Products 2

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
16887105 View Documents missing translation for 'viewProductCertificates'	Proteintech 60137-1-IG-20UL	20 μL	This item is currently unavailable or has been discontinued. View the product page for possible alternatives.		N/A

16877105 View Documents missing translation for 'viewProductCertificates'	Proteintech 60137-1-IG-150UL	150 μL	This item is currently unavailable or has been discontinued. View the product page for possible alternatives.		N/A

Description

Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71, and P72, but can not recognize NUMBL.

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Specifications

Antigen	NUMB
Concentration	2 mg/mL
Classification	Monoclonal
Form	Liquid
Regulatory Status	RUO
Formulation	PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Alias	h Numb, NUMB, numb homolog (Drosophila), Protein numb homolog, Protein S171, S171
Gene Symbols	Numb
Isotype	IgG2a
Purification Method	Caprylic Acid Precipitation
Product Type	Antibody

Clone	2G12B7
Applications	Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
Conjugate	Unconjugated
Host Species	Mouse
Target Species	Mouse, Human, Rat
Gene Accession No.	P49757, Q2LC84, Q9QZS3
Gene ID (Entrez)	18222, 29419, 8650
Immunogen	peptide
Primary or Secondary	Primary
Content And Storage	-20°C
Gene	NUMB

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NUMB Mouse anti-Human, Mouse, Rat, Clone: 2G12B7, Proteintech

Specifications

Description

Specifications

Documents