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OTUD7B Mouse anti-Human, Clone: 2C12D9, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66276-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828005

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ′Lys-48′-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ′Lys-11′, ′Lys-48′ or ′Lys-63′- linked polyubiquitin chains. In vitro, has preference for ′Lys- 11′-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.
Specifications

Specifications

OTUD7B
2C12D9
Unconjugated
OTUD7B
Liquid
OTUD7B
OTUD7B Fusion Protein Ag10513
Protein A
RUO
Antibody
Monoclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6GQQ9
CEZANNE, OTU domain containing 7B, OTUD7B, ZA20D1, Zinc finger protein Cezanne
Mouse
IgG2b
20 μL
-20°C
Primary
56957
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