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P glycoprotein Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 22336-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.Specifications
| P glycoprotein | |
| Polyclonal | |
| Unconjugated | |
| ABCB1 | |
| ABCB1, CD243, GP170, MDR1, Multidrug resistance protein 1, P glycoprotein 1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 18669, 18671, 5243 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.48 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P06795, P08183, P21447 | |
| ABCB1, Abcb1a, Abcb1b | |
| P glycoprotein Fusion Protein Ag17811 | |
| 150 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |