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P-selectin Mouse anti-Human, Clone: 3G2C7, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 60322-1-IG-20UL

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Product Code. 16887415

  • 1645.54 SEK / 20µL

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Description

Description

P-Selectin, also called CD62, GRMP, GMP140 is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. The P-Selectin gene is mapped on 1q24.2. P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. In quiescent platelet, P-selectin is located on the inner wall of alpha-granules. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and suggested that SNX17 may function in the intracellular trafficking of P-selectin. P-selectin expression was found to be significantly and positively correlated with carotid artery stiffness and wall thickness, and the percentage of P-selectin-positive platelets was significantly higher in patients with carotid plaque.
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P-selectin Mouse anti-Human, Clone: 3G2C7, Proteintech > 20 μL; Unconjugated

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