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PAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14685-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16883444

  • 1355.00 SEK / 20µL
Estimated Shipment: 31-03-2023
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Description

Description

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. The second group includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
Specifications

Specifications

PAK4
Polyclonal
Unconjugated
PAK4
KIAA1142, p21 activated kinase 4, PAK 4, PAK4
Rabbit
Antigen Affinity Chromatography
RUO
10298, 292756, 70584
-20°C
Liquid
Immunocytochemistry, Immunoprecipitation, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
0.51 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O96013, Q8BTW9
Pak4
PAK4 Fusion Protein Ag5981
20 μL
Primary
Mouse, Rat, Human
Antibody
IgG
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