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PAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 14685-1-AP-20UL
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Description
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. The second group includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.Specifications
| PAK4 | |
| Polyclonal | |
| Unconjugated | |
| PAK4 | |
| KIAA1142, p21 activated kinase 4, PAK 4, PAK4 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 10298, 292756, 70584 | |
| -20°C | |
| Liquid |
| Immunofluorescence, Immunohistochemistry (Paraffin), Flow Cytometry, Immunoprecipitation, Immunocytochemistry | |
| 0.51 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O96013, Q8BTW9 | |
| Pak4 | |
| PAK4 Fusion Protein Ag5981 | |
| 20 μL | |
| Primary | |
| Human, Rat, Mouse | |
| Antibody | |
| IgG |
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Product Title
PAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated
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