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PDGFRA Mouse anti-Human, Clone: 2C11B8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 60045-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16876995

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

PDGFRA (PDGFR-alpha, Platelet Derived Growth Factor Receptor alpha) belongs to the protein tyrosine kinase family, and binds to the alpha chain of PDGF. PDGFR exhibits two different isoforms, alpha and beta, which are coded by two different genes. PDGF-alpha receptors are expressed in oligodendrocyte progenitor cells while PDGF-beta receptors are expressed on neurons. PDGFR possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind and activate only PDGFR alpha, while PDGF BB can bind and activate both PDGFR alpha and beta. Members of the PDGF receptor subfamily are cell surface receptors that act as mitogens for cells of mesenchymal origin, and consist of alpha and beta isoforms of approximately 190 and 125 kDa, respectively. Activated PDGF receptors act on signaling pathways that control cell growth, actin reorganization, migration, and differentiation. In humans, the gene is located on the q arm of chromosome 4. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Specifications

Specifications

PDGFRA
2C11B8
Unconjugated
PDGFRA
Liquid
PDGFRA
PDGFRA Fusion Protein Ag1385
Caprylic Acid Precipitation
RUO
Antibody
Monoclonal
Human
Western Blot
0.85 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P16234
CD140A, CD140a antigen, PDGF R alpha, PDGF receptor alpha, PDGFR2, PDGFRA, PDGFRalpha, PDGFR-alpha, Rhe PDGFRA
Mouse
IgG1
20 μL
-20°C
Primary
5156
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