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PDGFRA Mouse anti-Human, Clone: 2C11B8, Proteintech

Mouse Monoclonal Antibody

1236.20 SEK - 3313.85 SEK

Specifications

Antigen PDGFRA
Concentration 0.85 mg/mL
Applications Western Blot
Conjugate Unconjugated
Format Liquid
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16866995
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Proteintech
60045-1-IG-150UL
150 μL
3313.85 SEK
150µL
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Estimated Shipment: 31-01-2022
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16876995
View Documents Promotion Details
Proteintech
60045-1-IG-20UL
20 μL
1236.20 SEK
20µL
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Estimated Shipment: 31-01-2022
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Description

Description

PDGFRA (PDGFR-alpha, Platelet Derived Growth Factor Receptor alpha) belongs to the protein tyrosine kinase family, and binds to the alpha chain of PDGF. PDGFR exhibits two different isoforms, alpha and beta, which are coded by two different genes. PDGF-alpha receptors are expressed in oligodendrocyte progenitor cells while PDGF-beta receptors are expressed on neurons. PDGFR possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind and activate only PDGFR alpha, while PDGF BB can bind and activate both PDGFR alpha and beta. Members of the PDGF receptor subfamily are cell surface receptors that act as mitogens for cells of mesenchymal origin, and consist of alpha and beta isoforms of approximately 190 and 125 kDa, respectively. Activated PDGF receptors act on signaling pathways that control cell growth, actin reorganization, migration, and differentiation. In humans, the gene is located on the q arm of chromosome 4. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Specifications

Specifications

PDGFRA
Western Blot
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Monoclonal
-20°C
0.85 mg/mL
Unconjugated
Mouse
Human
IgG1
Caprylic Acid Precipitation
Antibody
SDS
Product Certifications