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Gibco™ PeproGMP® Human SCF Recombinant Protein, PeproTech®

Product Code. 30276212
50 μg, 50µg
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Quantity:
1 mg
100 μg
50 μg
Unit Size:
100µg
1mg
50µg
This item is not returnable. View return policy
This item is not returnable. View return policy

Recombinant Protein

The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

Specifications

Accession Number P21583
For Use With (Application) Functional Assay
Format Lyophilized
Formulation protein with no preservative
Gene ID (Entrez) 4254
Molecular Weight (g/mol) 18.4 kDa
Name PeproGMP™ Human SCF
Purification Method HPLC, SDS-PAGE
Quantity 50 μg
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Common Name SCF
Gene Symbol KITLG
Biological Activity Determined by the proliferation of TF-1 cells. PeproGMP Recombinant Human SCF has been tested against the WHO standard NIBSC 91/682.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA
Content And Storage -20°Cor to +80°C if preferred
Activity Determined by the proliferation of TF-1 cells. The specific activity of PeproGMP Recombinant Human SCF is 0.79 IU/ng, which is calibrated against NIBSC 91/682.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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Certificates

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1 results found
Lot Number Certificate Type Date Product Code
Lot Number0822G034-1I1322 Certificate TypeCertificate of Analysis Date01/05/2025 Product CodeGMP300-07-50UG
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