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Periostin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 19899-1-AP-20UL
Additional Details : Weight : 0.00010kg
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DescriptionPeriostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
|OSF 2, OSF2, Osteoblast specific factor 2, PDLPOSTN, Periostin, PN, POSTN, RP11 412K4.1|
|Antigen Affinity Chromatography|
|10631, 361945, 50706|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Periostin Fusion Protein Ag13791|
|Human, Rat, Mouse|