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Phospho-TDP43 (Ser403, Ser404) Mouse anti-Human, Mouse, Clone: 6B11B12, Proteintech

Mouse Monoclonal Antibody

1538.39 SEK - 4141.82 SEK

Specifications

Antigen Phospho-TDP43 (Ser403, Ser404)
Clone 6B11B12
Concentration 1.14 mg/mL
Applications Flow Cytometry, Western Blot
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16897625
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Proteintech
66079-1-IG-20UL
20 μL
1538.39 SEK
20µL
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Estimated Shipment: 02-04-2024
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16887625
View Documents Promotion Details
Proteintech
66079-1-IG-100UL
100 μL
4141.82 SEK
100µL
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Estimated Shipment: 02-04-2024
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Description

Description

Product No. 66079-1-Ig is a mouse monoclonal antibody recognizing TDP-43 only when phosphorylated at 403/404. Immunohistochemical analyses using this antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear stainin

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
Specifications

Specifications

Phospho-TDP43 (Ser403, Ser404)
1.14 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Tardbp
IgG2a
Protein A
Antibody
6B11B12
Flow Cytometry, Western Blot
Unconjugated
Mouse
Mouse, Human
Q13148, Q921F2
230908, 23435
Peptide
Primary
-20°C
TARDBP
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