Thermo Scientific™ Competition Rapid Equilibrium Dialysis (RED) Inserts
Evaluate competitive binding interactions by rapid equilibrium dialysis (RED) using this specially designed base plate and insert system.
Brand: Thermo Scientific™ 90088
Additional Details : Weight : 0.01000kg
Thermo Scientific™ Pierce Competition RED Device Inserts and Base Plates comprise a specially designed system for evaluating competitive binding interactions using the technique called rapid equilibrium dialysis (RED).The Competition RED Device was developed in association with pharmaceutical laboratories to more accurately model in vivo drug interactions by enabling equilibrium dialysis experiments to be performed in a multiplexed format involving competition for binding among different tissues. The system consists of disposable dialysis tube inserts and a reusable base plate made of high-grade PTFE. The Competition Base Plate is much like our regular RED Device Base Plate except that it is divided into different size chambers (wells) for positioning 2 to 8 RED Device Inserts per well. The format enables competitive dialysis experiments involving 2 to 15 separate tissue or protein fluid samples. Each Competition RED Insert contains either one or two separate dialysis chambers (each package includes a selection of both types). The Competition RED Device requires no extensive assembly or specialized equipment, and each chamber/well is easily accessible from the top of the device.
Easy to use – disposable tubes require no presoaking step, assembly, or specialized equipment
Short incubation time – design provides high surface-to-volume ratio of membrane to sample, enabling equilibrium to be reached within 2 to 4 hours
Flexible format – base plate contains several different chamber sizes, enabling small molecule partitioning studies involving 2 to 16 tissue or protein samples without waste
Robust – compartmentalized design eliminates potential for cross-talk or leakage
Reproducible and accurate – perform controlled experiments with multiple tissues to obtain screening results that have high predictability for in vivo studies with animal models
Validated quality – base plate is composed of chemically inert high-grade PTFE, eliminating non-specific binding and risk of contamination; each lot is functionally tested in a protein binding assay for guaranteed performance
ADME-Tox studies for in vitro screening of drug partitioning between plasma and multiple tissues before in vivo experiments with animal models; Aids in determining formulation of drug dosage for in vivo studies; Drug-drug interaction studies; Competitive binding and dissociation constant determination for small molecules versus multiple targets
|Pierce Competition RED Device Inserts|
|Binding Equilibrium, Protein|
|Cellulose Membrane, Dialysis|