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PTP4A1/PRL1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11508-1-AP-150UL
Additional Details : Weight : 0.00010kg
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DescriptionThe protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
|HH72, PRL 1, PRL1, PTP(CAAX1), PTP(CAAXI), PTP4A1, PTPCAAX1|
|Antigen Affinity Chromatography|
|19243, 29463, 7803|
|Western Blot, Immunohistochemistry (Paraffin)|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q63739, Q78EG7, Q93096|
|PTP4A1/PRL1 Fusion Protein Ag2067|
|Rat, Mouse, Human|