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PUMA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 55120-1-AP-150UL
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Description
55120-1-AP can recognize PUMA alpha 21-24 kDa and PUMA beta 15-18 kDa.
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.Specifications
| PUMA | |
| Polyclonal | |
| Unconjugated | |
| BBC3 | |
| BBC3, JFY 1, JFY1, PUMA | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 170770, 27113, 317673 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.3 mg/mL | |
| 0.1 M glycine, 0.1 M sodium bicarbonate with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q80ZG6, Q99ML1, Q9BXH1 | |
| Bbc3 | |
| Peptide | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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Product Title
PUMA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 150 μL; Unconjugated
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