missing translation for 'onlineSavingsMsg'
PUMA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 55120-1-AP-150UL
Additional Details : Weight : 0.00010kg
VideosSDSDocumentsCertificates Special Offers
55120-1-AP can recognize PUMA alpha 21-24 kDa and PUMA beta 15-18 kDa.PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
|BBC3, JFY 1, JFY1, PUMA|
|Antigen Affinity Chromatography|
|170770, 27113, 317673|
|Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)|
|0.1 M glycine, 0.1 M sodium bicarbonate with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q80ZG6, Q99ML1, Q9BXH1|
|Rat, Mouse, Human|