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RAB11A Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20229-1-AP-150UL
Additional Details : Weight : 0.00010kg
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The antibody is specific to RAB11A, and has no cross reaction to RAB11B.Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
|Rab 11, RAB11, RAB11A, Ras related protein Rab 11A, YL8|
|Antigen Affinity Chromatography|
|Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|