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RAG2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 11825-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
This gene encodes a protein that is involved in the initiation of VJ recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.Specifications
RAG2 | |
Polyclonal | |
Unconjugated | |
RAG2 | |
RAG 2, RAG2 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
19374, 5897 | |
-20°C | |
Liquid |
Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Flow Cytometry | |
0.13 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P21784, P55895 | |
RAG2 | |
RAG2 Fusion Protein Ag2393 | |
150 μL | |
Primary | |
Mouse, Human | |
Antibody | |
IgG |