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RBM25 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 25297-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16823885

  • 1236.20 SEK / 20µL
Estimated Shipment: 02-12-2021

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Description

Description

RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5′-splice site (5′-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5′-ss usage through the 5′-CGGGCA-3′ RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5′ ss in a 5′-CGGGCA-3′-dependent manner. Binds to the exonic splicing enhancer 5′-CGGGCA-3′ RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
Specifications

Specifications

RBM25
0.25 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
B2RY56, P49756
fSAP94, NET52, Protein S164, RBM25, RED120, RNA binding motif protein 25, RNA binding protein 25, RNPC7, S164
Rabbit
IgG
20 μL
-20°C
Primary
58517, 67039
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
RBM25
Liquid
RBM25
RBM25 Fusion Protein Ag18244
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human
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Special Offers

Special Offers